Members of the Alliance for Human Relevant Science were devastated to hear the news of the tragic passing of Sir David Amess on Friday 15th October. Sir David was Vice Chair of the APPG for Human Relevant Science and understood the way in which human health could be improved without the need to use animals. He supported the launch of our Whitepaper in March 2020 and was keen to see change in biomedical science for the benefit of all. Above all, he was approachable, caring and genuinely interested in our cause. His compassion was clear and is reflected in the many tributes now being paid for his charitable work and steadfast dedication to the constituents he represented. He will be sorely missed and our heartfelt condolences go out to his family, friends and colleagues.